The most serious adverse effect of dipyrone is on the bone marrow. It depresses the bone marrow activity which results in a decrease of protective white blood cells (agranulocytosis). This adverse effect occurs on the second or repeated exposure to the drug due to the formation of antibodies against it. Once these are formed, a subsequent use produces an allergic effect which can be fatal.  The incidence of this adverse effect has been approximately 0.8% in UK and 0.01% in Germany.

Other adverse effects include irritation of the stomach which is considerably more than that caused by aspirin. Prolonged use may prove to be toxic to the kidneys. Furthermore, skin rashes and asthma can also be caused due to allergy.

 

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